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使用缺氧/SU5416模型对小鼠的肺高血压进行诱导和特征

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JoVE Journal Medicine

Induction and Characterization of Pulmonary Hypertension in Mice using the Hypoxia/SU5416 Model

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使用缺氧/SU5416模型对小鼠的肺高血压进行诱导和特征

DOI:

10.3791/59252-v

•

07:10 min

•

June 03, 2020

•

Olympia Bikou, Roger J. Hajjar, Lahouaria Hadri, Yassine Sassi

¹Cardiovascular Research Center,Icahn School of Medicine at Mount Sinai, ²Phospholamban Foundation

Chapters

00:04Introduction
00:41Pulmonary Hypertension (PH) Induction
02:12Intubation
04:23Right Ventricular (RV) Pressure Measurement
05:39Results: Representative Mouse Pulmonary Hypertension Characterization
06:36Conclusion

Summary

Automatic Translation

该协议描述了小鼠肺高血压（PH）的诱导，基于暴露于缺氧和VEGF受体拮抗剂的注射。动物在协议启动3周后出现PH和右心室（RV）肥大。介绍了模型的功能和形态特征。

Tags

Keywords: Pulmonary Hypertension Hypoxia/SU5416 Model Right Ventricle Induction Procedure SU5416 Injection Hypoxia Exposure Pressure Measurement Pressure Volume Catheter Anesthesia Temperature Monitoring

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