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Induktion och karakterisering av pulmonell hypertoni hos möss med hypoxi/SU5416-modellen
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Induktion och karakterisering av pulmonell hypertoni hos möss med hypoxi/SU5416-modellen

Article DOI: 10.3791/59252-v • 07:10 min • June 3rd, 2020
June 3rd, 2020 •
1, 2, 1, 1
1Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, 2Phospholamban Foundation

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Detta protokoll beskriver induktion av lunghypertension (PH) hos möss baserat på exponeringen för hypoxi och injektion av en VEGF-receptorantagonist. Djuren utvecklar PH och höger ventrikulära (RV) hypertrofi 3 veckor efter inledandet av protokollet. Modellens funktionella och morfinmetriska karakterisering presenteras också.

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Medicin Hypoxi SU5416 Sugen pulmonell hypertoni PH höger ventrikulärt tryck pulmonell vaskulär ommodellering höger ventrikulär ommodellering
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