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Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform
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JoVE Journal Biology
Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

DOI:
10.3791/60569-v

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06:27 min

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October 20, 2020

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, ,
1Department of Biomedical Engineering,Texas A&M University

Chapters

  • 00:04Introduction
  • 00:33Polybubble Formation
  • 01:55Cargo Centering
  • 02:40Small Molecule Cargo Release and Near Infrared (NIR) Polybubble Activation
  • 04:25Results: Representative NIR Sensitive, Core-Shell Vaccine Delivery Platform Fabrication
  • 05:57Conclusion

Summary

Automatic Translation

Automatic Translation

This article describes the protocols used to produce a novel vaccine delivery platform, "polybubbles," to enable delayed burst release. Polyesters including poly(lactic-co-glycolic acid) and polycaprolactone were used to form the polybubbles and small molecules and antigen were used as cargo.

Tags

Keywords: Near-infraredVaccine DeliveryPolybubbleCargo StabilityPCLPLGADAPhotopolymerizationCargo EncapsulationSmall Molecule ReleaseConfocal Microscopy

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