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Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy
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JoVE Journal Neuroscience
Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

DOI:
10.3791/60831-v

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05:03 min

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April 17, 2020

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, , , , , ,
1Department of Surgery Campus Charité Mitte/Campus Virchow-Klinikum,Charité – Universitätsmedizin Berlin, 2Department of Visceral, Transplant and Thoracic Surgery,Medical University of Innsbruck, 3Charité Clinician Scientist Program,Berlin Institute of Health, 4Department of Psychiatry, Psychotherapy and Psychosomatics,RWTH Aachen University, 5Department of Cardiothoracic Surgery,University Medical Center Regensburg, 6Department of General, Visceral and Vascular Surgery,Charité – Universitätsmedizin Berlin

Chapters

  • 00:05Introduction
  • 00:38Arterial Catheterization
  • 01:48Tracheostomy
  • 02:26Brain Death Induction
  • 03:26Brain Death (BD) Monitoring
  • 03:54Results: Representative Mean Arterial Pressure (MAP) Measurement and Immune System Activation
  • 04:23Conclusion

Summary

Automatic Translation

Automatic Translation

We present a murine model of brain death induction in order to evaluate the influence of its pathophysiological effects on organs as well as on consecutive grafts in the context of solid organ transplantation.

Tags

Keywords: Brain DeathIntra-arterial Blood PressureVentilationTracheostomyMouse ModelOrgan TransplantationInflammatory ResponseArterial CatheterizationCommon Carotid ArteryTracheal IntubationBrain InjuryBalloon Catheter

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