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合成阿普塔默-PEI-g-PEG改性金纳米粒子装载多索鲁比辛用于靶向药物输送
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Chemistry
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JoVE Journal
Chemistry
Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
Please note that all translations are automatically generated.
Click here for the English version.
合成阿普塔默-PEI-g-PEG改性金纳米粒子装载多索鲁比辛用于靶向药物输送
DOI:
10.3791/61139-v
•
09:09 min
•
June 23, 2020
•
Lei Nie
2
,
Shaolan Sun
,
Meng Sun
,
Qiuju Zhou
,
Zongwen Zhang
,
Lingyun Zheng
,
Lingling Wang
1
College of Life Sciences
,
Xinyang Normal University
,
2
Department of Imaging & Pathology, University of Leuven and Oral & Maxillofacial Surgery
,
University Hospitals Leuven
,
3
Analysis & Testing Center
,
Xinyang Normal University
Chapters
00:04
Introduction
00:34
Double-Carboxyl Polyethylene Glycol (CT-PEG) Synthesis
02:15
Poly(ethylenimine) Grafted with Polyethylene Glycol (PEI-g-PEG ) Copolymer Synthesis
04:03
PEI-g-PEG Coated Gold Nanoparticles (@AuNPs) Synthesis
05:05
DOX-g-PEI-g-PEG@AuNP Synthesis
06:11
AS1411-g-DOX-g-PEI-g-PEG@AuNP Synthesis
07:13
Results: Representative AuNP Characterization
08:33
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
在此协议中,多索鲁比辛加载 AS1411-g-PEI-g-PEG 改性金纳米粒子通过三步阿米内反应合成。然后,多索鲁比辛被加载并交付给靶向癌细胞进行癌症治疗。
Tags
Doxorubicin
Drug Delivery
Gold Nanoparticles
Aptamer
PEI-g-PEG
CT-PEG
Targeted Drug Delivery
Cancer Treatment
Drug Resistance
Toxicity
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