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合成阿普塔默-PEI-g-PEG改性金纳米粒子装载多索鲁比辛用于靶向药物输送

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Chemistry

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JoVE Journal Chemistry

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

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合成阿普塔默-PEI-g-PEG改性金纳米粒子装载多索鲁比辛用于靶向药物输送

DOI:

10.3791/61139-v

•

09:09 min

•

June 23, 2020

•

Lei Nie², Shaolan Sun, Meng Sun, Qiuju Zhou, Zongwen Zhang, Lingyun Zheng, Lingling Wang

¹College of Life Sciences,Xinyang Normal University, ²Department of Imaging & Pathology, University of Leuven and Oral & Maxillofacial Surgery,University Hospitals Leuven, ³Analysis & Testing Center,Xinyang Normal University

Chapters

00:04Introduction
00:34Double-Carboxyl Polyethylene Glycol (CT-PEG) Synthesis
02:15Poly(ethylenimine) Grafted with Polyethylene Glycol (PEI-g-PEG ) Copolymer Synthesis
04:03PEI-g-PEG Coated Gold Nanoparticles (@AuNPs) Synthesis
05:05DOX-g-PEI-g-PEG@AuNP Synthesis
06:11AS1411-g-DOX-g-PEI-g-PEG@AuNP Synthesis
07:13Results: Representative AuNP Characterization
08:33Conclusion

Summary

Automatic Translation

在此协议中，多索鲁比辛加载 AS1411-g-PEI-g-PEG 改性金纳米粒子通过三步阿米内反应合成。然后，多索鲁比辛被加载并交付给靶向癌细胞进行癌症治疗。

Tags

Keywords: Doxorubicin Drug Delivery Gold Nanoparticles Aptamer PEI-g-PEG CT-PEG Targeted Drug Delivery Cancer Treatment Drug Resistance Toxicity

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