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Syntese av Aptamer-PEI-g-PEG Modifisert Gull Nanopartikler Lastet med Doxorubicin for målrettet legemiddellevering
JoVE Journal
Chemistry
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JoVE Journal Chemistry
Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
DOI:

09:09 min

June 23, 2020

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Chapters

  • 00:04Introduction
  • 00:34Double-Carboxyl Polyethylene Glycol (CT-PEG) Synthesis
  • 02:15Poly(ethylenimine) Grafted with Polyethylene Glycol (PEI-g-PEG ) Copolymer Synthesis
  • 04:03PEI-g-PEG Coated Gold Nanoparticles (@AuNPs) Synthesis
  • 05:05DOX-g-PEI-g-PEG@AuNP Synthesis
  • 06:11AS1411-g-DOX-g-PEI-g-PEG@AuNP Synthesis
  • 07:13Results: Representative AuNP Characterization
  • 08:33Conclusion

Summary

Automatic Translation

I denne protokollen syntetiseres doksorubicinbelastede AS1411-g-PEI-g-PEG-modifiserte gull nanopartikler via tre-trinns midt i reaksjoner. Deretter lastes doksorubicin og leveres for å målrette kreftceller for kreftbehandling.

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