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Neuroscience
/
测量一组啮齿动物脑样本中的中风后脑水肿、梗塞区和血脑屏障破裂
JoVE Journal
Neuroscience
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JoVE Journal
Neuroscience
Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples
Please note that all translations are automatically generated.
Click here for the English version.
测量一组啮齿动物脑样本中的中风后脑水肿、梗塞区和血脑屏障破裂
DOI:
10.3791/61309-v
•
04:32 min
•
October 23, 2020
•
Dmitry Frank*
1
,
Benjamin F. Gruenbaum*
2
,
Julia Grinshpun
,
Israel Melamed
,
Olena Severynovska
,
Ruslan Kuts
,
Michael Semyonov
,
Evgeni Brotfain
,
Alexander Zlotnik
,
Matthew Boyko
1
Department of Anesthesiology and Critical Care, Soroka Medical Center
,
Ben-Gurion University of the Negev
,
2
Department of Anesthesiology
,
Yale University School of Medicine
,
3
Department of Neurosurgery, Soroka University Medical Center and the Faculty of Health Sciences
,
Ben-Gurion University of the Negev
,
4
Department of Physiology, Faculty of Biology, Ecology and Medicine
,
Dnepropetrovsk State University
Chapters
00:04
Introduction
00:54
Determination of Infarct Zone and Brain Edema
02:37
Determination of BBB Disruption
03:23
Results: Histological Outcomes of MCAO Rats Compared to Sham-operated Rats
03:57
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
此协议描述了在同一组啮齿动物脑样本上测量缺血性脑损伤三个最重要的参数的新技术。仅使用一个大脑样本在道德和经济成本方面非常有利。
Tags
Stroke
Cerebral Edema
Infarct Zone
Blood-brain Barrier
BBB Permeability
Middle Cerebral Artery Occlusion
Ischemic Brain Injury
TTC Staining
ImageJ
Infarct Volume
Brain Edema
Trichloroacetic Acid
Luminescence Spectrophotometry
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