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Cancer Research

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为癌症药理学研究创建匹配的体内/体外患者衍生模型对 PDX 和 PDX 衍生器官
 
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为癌症药理学研究创建匹配的体内/体外患者衍生模型对 PDX 和 PDX 衍生器官

Article DOI: 10.3791/61382
May 5th, 2021

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Summary May 5th, 2021

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描述使用患者衍生的异种格拉夫特 (PDX) 进行体外筛查的方法,从而形成匹配的体内/体外模型对。PDX 肿瘤被机械或酶地收获/加工成小块,然后是 Clevers 的生长肿瘤器官的方法,这些器官是通过、冷冻保存和针对原始 PDX 进行特征的。

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