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Journal / Cancer Research / Skapa matchade in vivo/in vitro patient-härledda…
JoVE Journal
Cancer Research

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JoVE Journal Cancer Research
Skapa matchade in vivo/in vitro patient-härledda modellpar av PDX och PDX-härledda organoider för cancerfarmakologi forskning
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Skapa matchade in vivo/in vitro patient-härledda modellpar av PDX och PDX-härledda organoider för cancerfarmakologi forskning

Article DOI: 10.3791/61382-v • 04:49 min • May 5th, 2021
May 5th, 2021 •
1, 1, 2, 2, 2, 1, 2, 2, 1, 2, 3, 2, 2, 2, 3
1Crown Bioscience Inc., Changping District, Beijing, China, 2Crown Bioscience Inc., Taicang, Jiangsu, China, 3Crown Bioscience Inc., San Diego, CA, USA

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En metod beskrivs för att skapa organoider med patientbaserade xenografter (PDX) för in vitro-screening, vilket resulterar i matchade par in vivo/in vitro-modeller. PDX tumörer skördades/bearbetades i små bitar mekaniskt eller enzymatically, följt av Clevers metod att odla tumör organoider som passages, cryopreserved och karakteriseras mot den ursprungliga PDX.

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