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Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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Chapters
- 00:05Introduction
- 00:39Quartz Crystal Microbalance (QCM) Sensor Chip Preparation
- 01:56T7 Phage Library Biopanning
- 04:42Bioinformatics Analysis
- 06:03Results: Representative Global Validation of Drug-Protein Interactions
- 07:38Conclusion
This study aimed to present a strategy for identifying drug-peptide interactions. The strategy involves the biopanning of drug-recognizing short peptides based on a quartz-crystal microbalance (QCM) biosensor, followed by bioinformatics analysis for quantitatively assessing the information obtained for the drug recognition and annotation of the drug-binding sites on proteins.
