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Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology
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Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology

Article DOI: 10.3791/64355-v • 10:41 min • September 13th, 2022
September 13th, 2022 •
1, 1, 1, 1
1NMI Natural and Medical Sciences Institute at the University of Tübingen, Germany,

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Summary
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The combination of laser poration and microelectrode arrays (MEA) allows action potential-like recordings of cultivated primary and stem cell-derived cardiomyocytes. The waveform shape provides superior insight into test compounds' mode of action than standard recordings. It links patch-clamp and MEA readout to further optimize cardio safety research in the future.

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Laser-induced Action Potential-like Measurements Cardiomyocytes Microelectrode Arrays Safety Pharmacology AP Shape Pro-arrhythmic Potentials Field Potential Recordings Intracellular Potential Shape Ion Channels Stem Cell Technology Causal Diagnosis Personalization CRP Cardiac Diseases Fibronectin Coating Plating Solution Cell Suspension Cell Seating
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