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Chapters
- 00:05Title
- 01:43Sciatic Nerve Chronic Constriction
- 04:53Measurements of Mechanical Withdrawal Threshold and Thermal Withdrawal Latency
- 06:54Representative Results
- 07:35Conclusion
Due to the simplicity of surgery and the robust behavioural outcome, chronic constriction of the sciatic nerve is one of the pre-eminent animal models of neuropathic pain. Within 24 hrs following surgery, pain hypersensitivity is established and can be quantitatively measured using a von Frey aesthesiometer (mechanical test) and plantar analgesia meter (thermal test).
Tags
Chronic ConstrictionSciatic NervePain HypersensitivityNeuropathic PainCentral Nervous SystemPeripheral Nervous SystemSymptomsAllodyniaHyperalgesiaAnimal ModelsChronic Constriction InjuryCCIAnaesthesiaSkin IncisionChromic Gut LigaturesEpineural Blood FlowSuturesStaplesRecovery From SurgeryPain Hypersensitivity TestingBehavioural Testing
