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Biology

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Analysis of Skeletal Muscle Defects in Larval Zebrafish by Birefringence and Touch-evoke Escape Response Assays
 

Analysis of Skeletal Muscle Defects in Larval Zebrafish by Birefringence and Touch-evoke Escape Response Assays

Article DOI: 10.3791/50925-v 08:01 min December 13th, 2013
December 13th, 2013

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Summary

The zebrafish is now an established and powerful tool for modeling muscular dystrophies, congenital myopathies, and related neuromuscular diseases. Birefringence and touch-evoked escape behavior are two common noninvasive assays used to determine the degree of muscular disorganization and locomotive impairment of zebrafish embryos during early development.

Tags

Skeletal Muscle Defects Larval Zebrafish Birefringence Assay Touch-evoked Escape Response Assay Modeling Human Diseases Muscular Dystrophies Congenital Myopathies Sarcomeric Assembly Disruptions Zebrafish Locomotive Impairment Muscle Integrity Assessment Translucent Zebrafish Larvae Polarized Light Filters Muscle Mutants Muscular Dystrophies Modeling Myofiber Degeneration Necrosis Regeneration
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