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JoVE Journal
Biology

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High-throughput Physical Mapping of Chromosomes using Automated in situ Hybridization
 

High-throughput Physical Mapping of Chromosomes using Automated in situ Hybridization

Article DOI: 10.3791/4007 08:48 min
June 28th, 2012

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Summary June 28th, 2012

Genome assemblies based on massively parallel DNA sequencing technologies are usually highly fragmented. The development of physical chromosome maps can potentially improve genome assemblies. Here, we demonstrate innovative approaches to chromosome preparation, fluorescent in situ hybridization, and imaging that significantly increase throughput of the physical map development.

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