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JoVE Journal
Engineering

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Compact Quantum Dots for Single-molecule Imaging
 

Compact Quantum Dots for Single-molecule Imaging

Article DOI: 10.3791/4236
October 9th, 2012

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Summary October 9th, 2012

We describe the preparation of colloidal quantum dots with minimized hydrodynamic size for single-molecule fluorescence imaging. Compared to conventional quantum dots, these nanoparticles are similar in size to globular proteins and are optimized for single-molecule brightness, stability against photodegradation, and resistance to nonspecific binding to proteins and cells.

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