Journal
/
/
Real-time Imaging av Heterotypic Blodplate-nøytrofile interaksjoner på Aktivert Endotelet Under vaskulær inflammasjon og trombedannelse i levende mus
JoVE Journal
Immunology and Infection
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Immunology and Infection
Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice
DOI:

11:18 min

April 02, 2013

, ,

Chapters

  • 00:05Title
  • 01:20Intravital Microscope and Cremaster Muscle Preparation for Intravital Microscropy
  • 02:30Intravital Microscopy for TNFα-induced Vascular Inflammation
  • 03:33Data Analysis for the Venular Inflammation Model
  • 06:06Intravital Microscopy for Laser-induced Arteriolar Thrombosis
  • 06:58Data Analysis for the Arteriolar Thrombosis Model
  • 08:20Results: Representative Heterotypic Interactions of Platelets and Neutrophils during TNFα-induced Vascular Inflammation and Platelet Thrombus at the Site of Laser-induced Arteriolar Injury in Live Mice
  • 10:52Conclusion

Summary

Automatic Translation

Her rapporterer vi en eksperimentell teknikk av fluorescens intravital mikroskop for å visualisere heterotypic blodplatelignende nøytrofile interaksjoner på aktivert endotel under vaskulær inflammasjon og trombedannelse i levende mus. Denne mikroskopiske teknologien vil være verdifullt å studere molekylære mekanismen for vaskulær sykdom og å teste farmakologiske stoffer i henhold patofysiologiske forhold.

Related Videos

Read Article