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Chapters
- 00:05Title
- 01:57Stage One: Sequence Selection
- 05:22Stage Two: Fold Specificity Calculations
- 06:35Stage Three: Approximate Binding Affinity Calculations for Protein-peptide Complexes
- 07:38Results: De novo Design of Entry Inhibitors for HIV-1
- 09:59Conclusion
We developed computational de novo protein design methods capable of tackling several important areas of protein design. To disseminate these methods we present Protein WISDOM, an online tool for protein design (http://www.proteinwisdom.org). Starting from a structural template, design of monomeric proteins for increased stability and complexes for increased binding affinity can be performed.
