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Immunology and Infection

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JoVE Journal Immunology and Infection
Generatie van recombinant arenavirus for Vaccine Development in FDA-goedgekeurde Vero cellen
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Generatie van recombinant arenavirus for Vaccine Development in FDA-goedgekeurde Vero cellen

Article DOI: 10.3791/50662
August 1st, 2013 •
*1, *1, 2, 1
1Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 2Departments of Immunology and Microbial Sciences, The Scripps Research Institute
* These authors contributed equally

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August 1st, 2013

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Redding van recombinant arenavirussen uit gekloneerde cDNA's, gegeven voor een reverse genetische benadering stelt onderzoekers de rol van specifieke virale genproducten, evenals de bijdrage van de verschillende specifieke gebieden en residuen te onderzoeken, om verschillende aspecten van de biologie van arenavirus . Ook reverse genetics technieken FDA-goedgekeurde cellijnen (Vero) voor vaccinontwikkeling verschaft nieuwe mogelijkheden voor het genereren van effectieve en veilige vaccins ter bestrijding humane pathogene arenavirussen.

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