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建立了外科手术引起的小鼠模型,以调查的progranulin在骨性关节炎的保护作用
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Establishment of a Surgically-induced Model in Mice to Investigate the Protective Role of Progranulin in Osteoarthritis
DOI:

07:58 min

February 25, 2014

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Chapters

  • 00:05Title
  • 01:30Surgery
  • 04:06Histological Scoring of Surgical DMM Model
  • 06:19Results: Deficiency of PGRN Increases the Surgically-induced Osteoarthritis Development in DMM Mice
  • 07:32Conclusion

Summary

Automatic Translation

我们描述了一个协议内侧半月板(DMM)模型小鼠中,一种有效的工具,骨关节炎(OA)研究的不稳定。此外,我们已经证明progranulincan夸大OA的发生和发展利用该模型的不足,表明progranulin的发挥在OA的发病机制中起保护作用。

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