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Etablering af et kirurgisk induceret model i mus for at undersøge den beskyttende rolle i Progranulin i Slidgigt
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Bioengineering
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JoVE Journal Bioengineering
Establishment of a Surgically-induced Model in Mice to Investigate the Protective Role of Progranulin in Osteoarthritis

Etablering af et kirurgisk induceret model i mus for at undersøge den beskyttende rolle i Progranulin i Slidgigt

DOI:
10.3791/50924-v

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07:58 min

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February 25, 2014

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, ,
1Department of Orthopaedic Surgery,NYU Hospital for Joint Diseases, 2Department of Orthopaedic Surgery,New York University Medical Center

Chapters

  • 00:05Title
  • 01:30Surgery
  • 04:06Histological Scoring of Surgical DMM Model
  • 06:19Results: Deficiency of PGRN Increases the Surgically-induced Osteoarthritis Development in DMM Mice
  • 07:32Conclusion

Summary

Automatic Translation

Automatic Translation

Vi beskriver en protokol for en destabilisering af den mediale menisk (DMM) model i mus, et effektivt redskab for slidgigt (OA) forskning. Desuden har vi påvist, at mangel på progranulincan overdrive OA udvikling og progression ved hjælp af denne model, hvilket indikerer, at progranulin spiller en beskyttende rolle i patogenesen for OA.

Tags

OsteoarthritisDestabilization Of Medial Meniscus (DMM)Progranulin (PGRN)Surgically-induced ModelCartilage DegradationOsteophyte FormationGene Expression

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