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Fremgangsmåde til screening og validering af resistente mutationer Against kinaseinhibitorer
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Fremgangsmåde til screening og validering af resistente mutationer Against kinaseinhibitorer

Article DOI: 10.3791/51984-v • 12:40 min • December 7th, 2014
December 7th, 2014 •
1, 1, 1, 1
1Divisions of Experimental Hematology and Cancer Pathology, Cancer Blood Disease Institute, Cincinnati Children's Hospital Medical Center

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Fremkomsten af ​​genetisk resistens over for kinase hæmmere udgør en betydelig udfordring for effektiv kræftbehandling. Identifikation og karakterisering af resistente mutationer mod en nyudviklet lægemiddel hjælper med bedre kliniske håndtering og næste generation drug design. Her beskriver vi vores protokol for in vitro screening og validering af resistente mutationer.

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Genetik JAK2 BCR / ABL TKI tilfældig mutagenese resistens kinaseinhibitorer,
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