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Personlig peptid Arrays for påvisning af HLA Alloantibodies i organtransplantation
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1Division of Nephrology and Hypertension, and the Center for Kidney Research and Therapeutics at the Feinberg Cardiovascular Research Institute,Northwestern University Feinberg School of Medicine, 2Surgery-Organ Transplantation,Northwestern University Feinberg School of Medicine, 3School of Biological Sciences and Medical Engineering,Southeast University
Chapters
- 00:05Title
- 00:55Donor and Recipient HLA Sequence Bioinformatic Analysis and Custom Array Synthesis
- 03:19Probe the Pre- and Post-Transplant Sera
- 05:06Data Acquisition and Analysis
- 06:11Results: Representative Recipient anti-Donor HLA Alloantibody Detection
- 07:36Conclusion
Uoverensstemmelser i human leukocyt antigen (HLA) sekvenser mellem organdonor og modtagende par er den største årsag til antistof-medieret afvisning i organtransplantation. Her præsenterer vi brugen af brugerdefinerede antigen arrays, der er baseret på individuelle donorer HLA sekvenser at sonde anti-donor HLA alloantibodies i orgel modtagere.
