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JoVE Journal
Immunology and Infection

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Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein
 

Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein

Article doi: 10.3791/56401
December 20th, 2017

Summary December 20th, 2017

Qa-1 (HLA-E in human) belongs to a group of non-classical major histocompatibility complex 1b molecules. Immunization with Qa-1-binding epitopes has been shown to augment tissue-specific immune regulation and ameliorate several autoimmune diseases. Herein we describe an overlapping peptide library strategy for the identification of Qa-1 epitopes in a protein.

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