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后半圆管法在新生小鼠内耳基因传递中的研究
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JoVE Journal Medicine
Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse
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后半圆管法在新生小鼠内耳基因传递中的研究

DOI:
10.3791/56648-v

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03:52 min

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March 02, 2018

•

,
1National Institute on Deafness and Other Communication Disorders,National Institutes of Health, 2Department of Otolaryngology-Head & Neck Surgery,Johns Hopkins School of Medicine

Chapters

  • 00:05Title
  • 00:32Procedure Setup
  • 01:08Surgical Approach
  • 02:35Results: Transduction of Utricular and Cochlear Hair Cells
  • 03:22Conclusion

Summary

Automatic Translation

Automatic Translation

在本研究中, 我们描述了后半圆管方法作为一种可靠的方法, 为内耳基因分娩的新生小鼠。我们表明, 通过后半规管的基因传递能够灌注整个内耳。

Tags

Posterior Semicircular CanalInner Ear Gene DeliveryNeonatal MouseAAV8-whirlinGene TherapyHair Cell TransductionStereocilia ElongationSurgical DissectionMicro-injection

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