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JoVE Journal

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Promoter Capture Hi-C

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

Article DOI: 10.3791/57320
June 28th, 2018


Summary June 28th, 2018

DNA regulatory elements, such as enhancers, control gene expression by physically contacting target gene promoters, often through long-range chromosomal interactions spanning large genomic distances. Promoter Capture Hi-C (PCHi-C) identifies significant interactions between promoters and distal regions, enabling the assignment of potential regulatory sequences to their target genes.


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