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JoVE Journal
Genetics

This content is Open Access.

Promoter Capture Hi-C
 

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

Article doi: 10.3791/57320
June 28th, 2018

Summary June 28th, 2018

DNA regulatory elements, such as enhancers, control gene expression by physically contacting target gene promoters, often through long-range chromosomal interactions spanning large genomic distances. Promoter Capture Hi-C (PCHi-C) identifies significant interactions between promoters and distal regions, enabling the assignment of potential regulatory sequences to their target genes.

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