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JoVE Journal
Cancer Research

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Paramyxoviruses for Tumor-targeted Immunomodulation

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Article DOI: 10.3791/58651-v
January 7th, 2019


Summary January 7th, 2019

This protocol describes a detailed workflow for the generation and ex vivo characterization of oncolytic viruses for expression of immunomodulators, using measles viruses encoding bispecific T cell engagers as an example. Application and adaptation to other vector platforms and transgenes will accelerate the development of novel immunovirotherapeutics for clinical translation.


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