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Cancer Research
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利用血脑肿瘤屏障在盘中进行活体有效载荷传递预测
JoVE Journal
Cancer Research
This content is Free Access.
JoVE Journal
Cancer Research
Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish
Please note that all translations are automatically generated.
Click here for the English version.
利用血脑肿瘤屏障在盘中进行活体有效载荷传递预测
DOI:
10.3791/59384-v
•
13:34 min
•
April 16, 2019
•
Vadim Le Joncour
,
Sinem Karaman
2
,
Pirjo Maarit Laakkonen
3
1
Research Programs Unit, Translational Cancer Medicine Research Program
,
University of Helsinki
,
2
Wihuri Research Institute, Biomedicum Helsinki
,
University of Helsinki
,
3
Laboratory Animal Center, Helsinki Institute of Life Science (HiLIFE)
,
University of Helsinki
Chapters
00:04
Title
02:12
Preparation of Astrocytes
04:08
Preparation of Endothelial Cells
06:10
Preparation of Glioma Cells
07:43
Measurement of the BBTB Mimic Permeability (Optional)
08:48
BBTB Fluorescence Staining to Detect Nanoparticle Transcytosis
10:08
Results: Analysis of In Vivo Payload Delivery using the Blood-brain Tumor-barrier
12:25
Conclusion
Summary
Automatic Translation
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Automatic Translation
针对中枢神经系统肿瘤的药物靶向是一项重大挑战。在这里, 我们描述了一个协议, 以产生一个体外模拟血脑肿瘤屏障使用小鼠和/或人类细胞, 并讨论其与中枢神经系统肿瘤靶向在体内的相关性。
Tags
Blood-brain Barrier
Blood-brain Tumor Barrier
In Vitro Model
Cell Culture
Astrocytes
Brain Tumor Cells
Drug Delivery
Drug Diffusion
Quantification
Visualization
Preclinical Models
Patient Heterogeneity
Reproducibility
Immortalized Cells
Cell Seeding
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