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干细胞衍生病毒Ag特异性T淋巴细胞抑制小鼠HBV复制
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Immunology and Infection
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JoVE Journal Immunology and Infection
Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
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干细胞衍生病毒Ag特异性T淋巴细胞抑制小鼠HBV复制

DOI:
10.3791/60043-v

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07:25 min

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September 25, 2019

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, , ,
1Department of Microbial Pathogenesis and Immunology,Texas A&M University Health Science Center, 2Department of Ophthalmology,Harvard Medical School

Chapters

  • 00:04Title
  • 00:34Antigen (Ag)‐ Specific CD8+ T cell Generation
  • 02:01Hydrodynamic Herpes B Virus (HBV) Plasmid Delivery for HBV Replication Induction
  • 02:43HBV Replication Reduction
  • 03:38HBV Replication Reduction Analysis
  • 05:30Results: Representative Effects of Stem Cell-Derived Viral Ag-Specific T Lymphocyte HBV Replication Suppression
  • 06:58Conclusion

Summary

Automatic Translation

Automatic Translation

这里介绍了一个协议，通过利用干细胞衍生病毒抗原（Ag）特异性T淋巴细胞的采用细胞转移（ACT），有效抑制小鼠乙型肝炎病毒（HBV）复制。这个程序可以适应潜在的基于ACT的HBV感染免疫治疗。

Tags

Keywords: Stem CellViral Antigen-specific T LymphocytesHBV ReplicationIPSC-derived T CellsAdoptive Cell TransferT Cell ReceptorHBV PlasmidHydrodynamic DeliveryCD8-positive T Cells

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