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Flerdimensjonal kokultur system for å modellere lungeplatekarsinom progresjon
JoVE Journal
Cancer Research
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JoVE Journal Cancer Research
Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
DOI:

07:53 min

March 17, 2020

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Chapters

  • 00:05Introduction
  • 00:52Plating TUM622 Cells in the Extracellular Matrix for 3D Culturing
  • 03:523D Coculturing of TUM622 Cells and CAFs (Cancer Associated Fibroblasts) in the Extracellular Matrix
  • 05:39Results: Growth and Morphology
  • 06:58Conclusion

Summary

Automatic Translation

Et in vitro-modellsystem ble utviklet for å fange vevarkitektoniske endringer under lungeplatekarsinom (LUSC) progresjon i en 3-dimensjonal (3D) co-kultur med kreft-assosierte fibroblaster (CAFs). Dette organoidsystemet gir en unik plattform for å undersøke rollene til ulike tumorcelle-iboende og ekstriniske endringer som modulerer tumorfenotypen.

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