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Cancer Research
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使用结构DNA改变分析和患者衍生异种移植测试癌症的靶向疗法
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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Please note that all translations are automatically generated.
Click here for the English version.
使用结构DNA改变分析和患者衍生异种移植测试癌症的靶向疗法
DOI:
10.3791/60646-v
•
10:27 min
•
July 25, 2020
•
Piyan Zhang
,
Irina V. Kovtun
2
1
Center for Individualized Medicine
,
Mayo Clinic
,
2
Department of Molecular Pharmacology and Experimental Therapeutics
,
Mayo Clinic
Chapters
00:00
Introduction
00:59
Selection of Therapeutic Targets
03:45
Tumor Engraftment and Maintenance
07:15
Testing Responses to Genomically Identified Targets in PDX Models
07:46
Representative Results
10:02
Conclusion
Summary
Automatic Translation
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Automatic Translation
在这里,我们提出了一个方案,以测试基于肿瘤的基因组构成选择的靶向疗法的疗效。该协议描述了结构DNA重组的识别和验证,将患者的肿瘤引入小鼠,并测试对相应药物的反应。
Tags
Cancer
Targeted Therapy
Structural DNA Alteration
Patient-derived Xenografts
Whole Genome Sequencing
Genomic Alteration
Druggable Changes
In Vivo Treatment
Treatment Efficacy
Algorithm
Microsequencing
Gene Symbols
Pathway Analysis
Fisher’s Exact Test
Druggable Genes
Gene Cards
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