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使用hiPSC衍生心肌细胞的缺血性心脏病模型和基于视频的心肌细胞收缩比较
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal
Medicine
Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes
Please note that all translations are automatically generated.
Click here for the English version.
使用hiPSC衍生心肌细胞的缺血性心脏病模型和基于视频的心肌细胞收缩比较
DOI:
10.3791/61104-v
•
05:06 min
•
May 05, 2020
•
Yun Liu*
1
,
Yin Liang*
1
,
Mengxue Wang*
1
,
Chen Wang
,
Heng Wei
,
Keiji Naruse
,
Ken Takahashi
1
Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
,
Okayama University
,
2
Institute of Laboratory Animals, Graduate School of Medicine
,
Kyoto University
Chapters
00:04
Introduction
01:05
Human Induced Pluripotent Stem Cell (hiPSC) Cardiac Differentiation Induction
02:30
Induced Pluripotent Stem Cell-Cardiomyocyte (iPS-CM) Contractility Assessment
03:15
Ischemia Exposure
03:42
Results: Representative Cardiac Cell Differentiation
04:27
Conclusion
Summary
Automatic Translation
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Automatic Translation
我们提出了一个缺血性心脏病的模型,使用从人类诱导多能干细胞中提取的心肌细胞,以及一种定量评估缺血引起的组织损伤的方法。该模型可为药物筛查和进一步研究缺血性心脏病提供一个有用的平台。
Tags
IPS Cells
Cardiomyocytes
Ischemic Heart Disease
Video Analysis
Cardiomyocyte Contraction
Human Heart Physiology
Personalized Drug Screening
HiPSC-derived Cardiomyocytes
Particle Image Velocimetry
Phase Contrast Microscopy
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