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Neuroscience
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在鼠模型中使用聚焦超声波打开位置特定血脑屏障开口的台面方法
JoVE Journal
Neuroscience
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JoVE Journal
Neuroscience
A Benchtop Approach to the Location Specific Blood Brain Barrier Opening using Focused Ultrasound in a Rat Model
Please note that all translations are automatically generated.
Click here for the English version.
在鼠模型中使用聚焦超声波打开位置特定血脑屏障开口的台面方法
DOI:
10.3791/61113-v
•
08:58 min
•
June 13, 2020
•
Megan Rich
,
Quentin Whitsitt
,
Farah Lubin
,
Mark Bolding
1
Department of Radiology
,
University of Alabama at Birmingham
,
2
Department of Neurobiology
,
University of Alabama at Birmingham
Chapters
00:05
Introduction
00:32
Intracranial Targeting Procedure
03:26
Focused Ultrasound Procedure
07:12
Results: Focused Ultrasound BBB Opening
08:43
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
用微泡剂聚焦超声波可以聚焦和瞬时打开血脑屏障。这项技术已被用于通过血脑屏障提供广泛的制剂。本文提供了一个详细的协议,本地化交付给啮齿动物的大脑有或没有MRI指导。
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Focused Ultrasound
Blood-brain Barrier
Rat Model
Micro-bubbles
MRI
Stereotaxic Frame
Brain Region
Anesthesia
Catheter
Tail Vein
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