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Journal / Cancer Research / CRISPR媒介ベース・エディタを用いた BRCA1…
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Cancer Research

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JoVE Journal Cancer Research
CRISPR媒介ベース・エディタを用いた BRCA1 バリアントの機能評価
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CRISPR媒介ベース・エディタを用いた BRCA1 バリアントの機能評価

Article DOI: 10.3791/61557-v • 09:22 min • February 28th, 2021
February 28th, 2021 •
1,2, 1,2, 1,2, 1,2, 1,2
1Department of Biomedical Sciences, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, 2Stem Cell Immunomodulation Research Center, University of Ulsan College of Medicine

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BRCA1突然変異を有する人々は、BRCA1変異体の機能の正確な評価を保証する癌を発症するリスクが高い。本明細書において、生細胞における標的C:GからT:A変換を可能にするCRISPR媒介シトシンベースエディタを用いたBRCA1変異体の機能評価用プロトコルについて説明した。

Tags

がん研究、問題168、CRISPR-Cas、ベース編集 、BE3、BRCA1、機能評価、ゲノム工学
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