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A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices
 

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices

Article DOI: 10.3791/62127-v
August 11th, 2021

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Summary August 11th, 2021

This method introduces a simple technique for the detection of endogenous monoamine release using acute brain slices. The setup uses a 48-well plate containing a tissue holder for monoamine release. Released monoamine is analyzed by HPLC coupled with electrochemical detection. Additionally, this technique provides a screening method for drug discovery.

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