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Construcción de un modelo de órgano en un chip de células musculares lisas de la aorta humana para recapitular la tensión biomecánica en la pared aórtica
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall
DOI:

11:47 min

July 06, 2022

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Chapters

  • 00:04Introduction
  • 01:03Primary Human Aortic Smooth Muscle Cell Isolation
  • 02:53Preparation of PDMS Chip
  • 05:29PDMS Chip Surface Treatment and Sterilization
  • 06:12Cell Seeding on the PDMS Chip and Cell Stretching Process
  • 08:23Preparation of the Mechanical Control System
  • 09:30Results: An HASMC‐Organ‐On‐A‐Chip Model to Precisely Control the Parameters of the Biomechanical Strain on the Aortic Wall
  • 11:03Conclusion

Summary

Automatic Translation

Aquí, desarrollamos un modelo de órgano en un chip de células musculares lisas de la aorta humana para replicar la tensión biomecánica in vivo de las células del músculo liso en la pared aórtica humana.

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