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Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens
JoVE Journal
Medicine
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JoVE Journal Medicine
Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens
DOI:

09:26 min

July 29, 2011

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Chapters

  • 00:05Title
  • 02:25Tissue Processing
  • 04:25Immunohistochemistry
  • 06:54Representative GBM Tissue Images
  • 08:29Conclusion

Summary

Automatic Translation

Here, we established a method for drug efficacy testing with surgical specimens of brain tumors, termed “tumor explant method”. With this method, we can evaluate drug efficacy without breaking the microenvironment of solid tumors. To validate reliability of this method, we describe representative data with our glioma specimen treated with the current first-line chemotherapeutic agent, temozolomide.

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