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Isometric Contractility Measurement of the Mouse Mesenteric Artery Using Wire Myography
JoVE Journal
Medicine
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JoVE Journal Medicine
Isometric Contractility Measurement of the Mouse Mesenteric Artery Using Wire Myography
DOI:

09:42 min

August 20, 2018

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Chapters

  • 00:04Title
  • 00:55Mouse Mesenteric Artery Dissection
  • 02:26Arterial Mounting
  • 05:30Normalization
  • 07:03Artery Contraction Recording
  • 08:18Results: Representative Tracings Showing the Normalization Procedure, Potentiation by High-K+ Solution, and Contraction
  • 08:47Conclusion

Summary

Automatic Translation

The wire myograph technique is used to investigate vascular smooth muscle functions and screen new drugs. We report a detailed protocol for measuring the isometric contractility of the mouse mesenteric artery and for screening new relaxants of vascular smooth muscle.

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