JoVE
JoVE
Faculty Resource Center
Research
Behavior
Biochemistry
Biology
Bioengineering
Cancer Research
Chemistry
Developmental Biology
Engineering
Environment
Genetics
Immunology and Infection
Medicine
Neuroscience
JoVE Journal
JoVE Encyclopedia of Experiments
JoVE Chrome Extension
Education
Biology
Chemistry
Clinical
Engineering
Environmental Sciences
Pharmacology
Physics
Psychology
Statistics
JoVE Core
JoVE Science Education
JoVE Lab Manual
JoVE Quiz
JoVE Business
Videos Mapped to your Course
Authors
Librarians
High Schools
About
Sign-In
Sign In
Contact Us
Research
JoVE Journal
JoVE Encyclopedia of Experiments
Education
JoVE Core
JoVE Science Education
JoVE Lab Manual
High Schools
EN
EN - English
CN - 中文
DE - Deutsch
ES - Español
KR - 한국어
IT - Italiano
FR - Français
PT - Português
EN
EN - English
CN - 中文
DE - Deutsch
ES - Español
KR - 한국어
IT - Italiano
FR - Français
PT - Português
Close
Research
Behavior
Biochemistry
Bioengineering
Biology
Cancer Research
Chemistry
Developmental Biology
Engineering
Environment
Genetics
Immunology and Infection
Medicine
Neuroscience
Products
JoVE Journal
JoVE Encyclopedia of Experiments
Education
Biology
Chemistry
Clinical
Engineering
Environmental Sciences
Pharmacology
Physics
Psychology
Statistics
Products
JoVE Core
JoVE Science Education
JoVE Lab Manual
JoVE Quiz
JoVE Business
Videos Mapped to Your Course
Teacher Resources
Get in Touch
Instant Trial
Log In
EN
EN - English
CN - 中文
DE - Deutsch
ES - Español
KR - 한국어
IT - Italiano
FR - Français
PT - Português
Journal
/
Immunology and Infection
/
BLT人性化的鼠标使用一个基于干细胞的基因治疗肿瘤模型的建立
JoVE Journal
Immunology and Infection
A subscription to JoVE is required to view this content.
Sign in or start your free trial.
JoVE Journal
Immunology and Infection
Using the BLT Humanized Mouse as a Stem Cell based Gene Therapy Tumor Model
Please note that all translations are automatically generated.
Click here for the English version.
BLT人性化的鼠标使用一个基于干细胞的基因治疗肿瘤模型的建立
DOI:
10.3791/4181-v
•
06:59 min
•
December 18, 2012
•
Dimitrios N. Vatakis
2,3
,
Gregory C. Bristol
2
,
Sohn G. Kim
2
,
Bernard Levin
2
,
Wei Liu
,
Caius G. Radu
,
Scott G. Kitchen
2,3
,
Jerome A. Zack
2,5
1
Department of Medicine, Division of Hematology-Oncology
,
David Geffen School of Medicine at UCLA
,
2
UCLA AIDS Institute
,
3
Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA
,
4
Department of Medical and Molecular Pharmacology
,
David Geffen School of Medicine at UCLA
,
5
Department of Microbiology, Immunology and Molecular Genetics
,
David Geffen School of Medicine at UCLA
Chapters
00:05
Title
01:26
Tissue Transplantation
05:27
Results: PET Imaging Is a More Sensitive and Accurate Way to Assess Tumor Regression and Clearance
06:41
Conclusion
Summary
Automatic Translation
English (Original)
العربية (Arabic)
中文 (Chinese)
Nederlands (Dutch)
français (French)
Deutsch (German)
עברית (Hebrew)
italiano (Italian)
日本語 (Japanese)
한국어 (Korean)
português (Portuguese)
русский (Russian)
español (Spanish)
Türkçe (Turkish)
Automatic Translation
这里描述的是使用人源化小鼠的肿瘤特异性T细胞的产生和表征。人胸腺组织和转基因的人类造血干细胞移植到免疫功能低下小鼠。这将导致在一个精心设计的人体免疫系统在体内的抗肿瘤免疫反应的检查允许的重组。
Tags
BLT Humanized Mouse
Stem Cell-based Gene Therapy
Tumor Model
Small Animal Models
Mice
Human Disease
Therapeutic Interventions
Mouse Immunity
Viral Diseases
Human Immunodeficiency Virus (HIV) Infection
Humanized Mouse Models
C. B 17 Scid/scid Mice
Human Fetal Thymus
Fetal Liver
Thy/liv (SCID-hu)
Adoptive Transfer Of Human Peripheral Blood Leukocytes (SCID-huPBL)
Physiologically Relevant Model
BLT Stands For Bone Marrow/liver/thymus
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) Immunocompromised Mice
Human Hematopoietic Stem Cell Transplant
HIV Infection And Latency
Article
Embed
ADD TO PLAYLIST
Usage Statistics
Related Videos
Multivirus特异性T细胞的生成,预防/治疗异基因造血干细胞移植后的病毒感染
在细菌粘附的研究剪应力
扩大目标,脐血细胞毒性T淋巴细胞,巨细胞病毒,EB病毒,腺病毒
移植物抗宿主病的诱导和<em在体内</em> T细胞监测中的应用MHC匹配的小鼠模型
基于细胞的流式细胞仪检测,以测量细胞毒活性
人源化的小鼠模型来研究细菌感染瞄准微血管
巨细胞病毒特异性的自动化细胞富集的T细胞用于使用细胞因子捕获系统的临床应用
类器官的模型传染病:人类的文化与小鼠胃组织体与幽门螺杆菌的显微注射
流式细胞仪为基础的检测方法的NK细胞功能的监控
基于CFSE-试验鼠皮肤树突状细胞的迁移习进引流淋巴结在与感染<em>牛分枝杆菌</em>卡介苗
Read Article