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JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
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PRP as a New Approach to Prevent Infection: Preparation and In vitro Antimicrobial Properties of PRP

Article DOI: 10.3791/50351
April 9th, 2013 •
1,2, 1,3,4
1Department of Orthopaedics, School of Medicine, West Virginia University, 2Department of Orthopaedics, Stem Cell Research Center, University of Pittsburgh, 3WVNano Initiative, 4Mary Babb Randolph Cancer Center

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Summary
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April 9th, 2013

Implant-associated infection is a significant clinical complication. This study describes an approach using platelet-rich plasma (PRP) to prevent implant-associated infections, presents the protocol for preparing PRP with constant platelet concentration, and reports the newly identified antimicrobial properties of PRP and related protocols for examining such antimicrobial properties in vitro.

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