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JoVE Journal
Immunology and Infection

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Fremstilling af rekombinant arenavirus for Vaccine Development i FDA-godkendte Vero celler
 
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Fremstilling af rekombinant arenavirus for Vaccine Development i FDA-godkendte Vero celler

Article DOI: 10.3791/50662
August 1st, 2013

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Summary August 1st, 2013

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Redning af rekombinante arenaviruses fra klonede cDNA'er, en tilgang kaldet reverse genetik, giver forskerne at undersøge betydningen af ​​specifikke virale genprodukter, samt bidrag af deres forskellige specifikke domæner og restprodukter til mange forskellige aspekter af biologi arenavirus . Ligeledes omvendt genetik teknikker i FDA-godkendte cellelinier (Vero) for udvikling af vacciner giver nye muligheder til generering af effektive og sikre vacciner til bekæmpelse af humane patogene arenaviruses.

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