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Biology

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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
 

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Article doi: 10.3791/51308
March 25th, 2014

Summary March 25th, 2014

Biochemical assays with recombinant human MHC II molecules can provide rapid, quantitative insights into immunogenic epitope identification, deletion, or design.  Here, a peptide-MHC II binding assay scaled to 384-well plates is described. This cost effective format should prove useful in the fields of protein deimmunization and vaccine design and development.

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