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建立一个人类多发性骨髓瘤异种移植模型中的鸡,研究肿瘤的生长,侵袭和血管生成
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Medicine
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JoVE Journal
Medicine
Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Please note that all translations are automatically generated.
Click here for the English version.
建立一个人类多发性骨髓瘤异种移植模型中的鸡,研究肿瘤的生长,侵袭和血管生成
DOI:
10.3791/52665-v
•
10:04 min
•
May 01, 2015
•
Agnieszka Martowicz*
1,4
,
Johann Kern*
1,2
,
Eberhard Gunsilius
,
Gerold Untergasser
3
1
Department of Internal Medicine V
,
Innsbruck Medical University
,
2
Oncotyrol GmbH
,
3
Tyrolean Cancer Research Institute
,
4
Division of Vascular Biology, Department of Medical Biochemistry and Biophysics
,
Karolinska Institute
Chapters
00:05
Title
02:09
Cell Culture and Lentiviral Transfection
03:20
3D-Multiple Myeloma Spheroid Model
04:47
3D Multiple Myeloma Xenograft Model in the CAM
06:17
Quantification of eGFP Protein by ELISA
07:03
Immunohistochemical Analysis of Blood Vessels and Invading Tumor Cells
08:05
Results: Bortezomib Treatment of Multiple Meyloma Xenografts
09:17
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
人多发性骨髓瘤(MM)细胞需要间质细胞和细胞外基质成分为存活和增殖的支持性微环境。我们建立了与植入人类骨髓瘤和间质细胞
体内
鸡胚模型来研究癌症药物对肿瘤的生长,侵袭和血管生成作用。
Tags
Multiple Myeloma
Xenograft Model
Chicken Chorioallantoic Membrane
3D Culture
Angiogenesis
Tumor Growth
Invasion
GFP Reporter
Mesenchymal Cells
Collagen
RPMI-8226
OPM-2
Therapeutic Screening
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