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Un criblables<em> In Vivo</em> Essai de modulateurs mitochondriale utilisant transgénique Bioluminescent<em> Caenorhabditis elegans</em
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Biology
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JoVE Journal Biology
A Screenable In Vivo Assay for Mitochondrial Modulators Using Transgenic Bioluminescent Caenorhabditis elegans
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Un criblables<em> In Vivo</em> Essai de modulateurs mitochondriale utilisant transgénique Bioluminescent<em> Caenorhabditis elegans</em

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9,792 Views

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11:43 min

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October 16, 2015

DOI:

10.3791/53083-v

DOI:
10.3791/53083-v

•

11:43 min
October 16, 2015

•

10 Views
, ,
1Institute of Medical Sciences,University of Aberdeen

Summary

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A protocol is described for in vivo detection of effects of mitochondrial inhibitors in the model organism Caenorhabditis elegans and for identification of potential enhancing compounds. This protocol can be used to screen drug libraries for compounds modulating mitochondrial function.

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Lagido, C., McLaggan, D., Glover, L. A. A Screenable In Vivo Assay for Mitochondrial Modulators Using Transgenic Bioluminescent Caenorhabditis elegans. J. Vis. Exp. (104), e53083, doi:10.3791/53083 (2015).

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