En kombineret 3D manipuleret væv<em> In vitro</em> /<em> I Silico</em> Lunge Tumor Model for Forudsigelse Drug Effektivitet i specifikke mutations baggrunde
We present a three-dimensional (3D) lung cancer model based on a biological collagen scaffold to study sensitivity towards non-small-cell-lung-cancer-(NSCLC)-targeted therapies. We demonstrate different read-out techniques to determine the proliferation index, apoptosis and epithelial-mesenchymal transition (EMT) status. Collected data are integrated into an in silico model for prediction of drug sensitivity.