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C57BL/6 小鼠自身免疫性神经炎的功能和病理评价的简易方法

JoVE Journal
Neuroscience

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JoVE Journal Neuroscience

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments

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C57BL/6 小鼠自身免疫性神经炎的功能和病理评价的简易方法

DOI:

10.3791/56455-v

•

07:30 min

•

November 09, 2017

•

David G. Gonsalvez, Jessica L. Fletcher, Sang Won Yoo, Rhiannon J. Wood, Simon S. Murray, Junhua Xiao

¹Department of Anatomy and Neuroscience, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences,The University of Melbourne

Chapters

00:05Title
01:02Experimental Autoimmune Neuritis (EAN) Motor Function Testing and Clinical Scoring
04:11Results: Representative Analysis of P0_180-199 Peptide-induced EAN Pathology
05:59Conclusion

Summary

Automatic Translation

本报告概述了一个简单的方法, 成功诱导实验性自身免疫神经炎 (一) 使用髓磷脂蛋白零 (P0)_180-199肽结合弗氏的完整佐剂和百日咳毒素。我们提出了一个复杂的范例, 能够准确地评估在这一过程中出现的功能性赤字和神经病的程度。

Tags

Keywords: Experimental Autoimmune Neuritis EAN Mouse Model Peripheral Neuropathy Motor Function Assessment Pertussis Toxin Mycobacterium Tuberculosis Complete Freund’s Adjuvant Gait Function Imaging System Clinical Scoring

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