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JoVE Journal Neuroscience
En enkel tilnærming til å indusere eksperimentelle Autoimmune nevritt i C57BL/6 mus for funksjonell og Neuropathological vurderinger
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En enkel tilnærming til å indusere eksperimentelle Autoimmune nevritt i C57BL/6 mus for funksjonell og Neuropathological vurderinger

Article DOI: 10.3791/56455-v • 07:30 min • November 9th, 2017
November 9th, 2017 •
1, 1, 1, 1, 1, 1
1Department of Anatomy and Neuroscience, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne

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Denne rapporten skisserer en enkel tilnærming til vellykket indusere eksperimentelle autoimmune nevritt (EAN) bruker myelin protein null (P0)180-199 peptid sammen med Freunds komplett adjuvant og kikhoste gift. Vi presenterer et sofistikert paradigme i stand til nøyaktig å vurdere omfanget av funksjonelle underskudd og neuropathology som forekommer i denne EAN.

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Nevrovitenskap problemet 129 eksperimentelle autoimmune nevritt axonal skade noder av Ranvier eksterne nerve demyelinisering musemodell
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