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酶联反应合成 l-赖氨酸手性氨基醇的研究

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Chemistry

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JoVE Journal Chemistry

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine

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酶联反应合成 l-赖氨酸手性氨基醇的研究

DOI:

10.3791/56926-v

•

09:14 min

•

February 16, 2018

•

Aurélie Fossey-Jouenne, Carine Vergne-Vaxelaire, Anne Zaparucha

¹Génomique Métabolique, Genoscope, Institut François Jacob,CEA, CNRS, Univ Evry, Univ Paris-Saclay

Chapters

00:04Title
00:48Semi-preparative One-pot Biocatalytic Reaction, Reaction Monitoring, and Product Analysis
03:17Semi-preparative One-pot Biocatalytic Reaction: Second and Third Steps
06:01Results: Investigation of Pyridoxal Phosphate Dependent Decarboxylase (PLP DC) Activities towards Hydroxy Lysine Derivatives
07:56Conclusion

Summary

Automatic Translation

手性氨基醇是在有机合成中用作支架的多功能分子。从 l-赖氨酸开始, 用酶催化的酶联反应合成氨基醇, 然后将相应羟基氨基酸的羧酸基团 diastereoselective羧.

Tags

Keywords: Enzymatic Cascade Reactions Chiral Amino Alcohols L-lysine Chiral Auxiliaries Pharmaceutical Therapy One-pot Procedure Deoxygenase KD-01 DNFB Derivatization HPLC Analysis Deoxygenase KD-02 Decarboxylase Dccpin PLP

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