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JoVE Journal
Genetics

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CRISPR-Mediated Reorganization of Chromatin Loop Structure
 

CRISPR-Mediated Reorganization of Chromatin Loop Structure

Article DOI: 10.3791/57457
September 14th, 2018

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Summary September 14th, 2018

Chromatin looping plays a significant role in gene regulation; however, there have been no technological advances that allow for selective and reversible modification of chromatin loops. Here we describe a powerful system for chromatin loop re-organization using CRISPR-dCas9 (CLOuD9), demonstrated to selectively and reversibly modulate gene expression at targeted loci.

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