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Retroductal 纳米微粒注射液对小鼠颌下腺的治疗
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Bioengineering
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JoVE Journal Bioengineering
Retroductal Nanoparticle Injection to the Murine Submandibular Gland
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Retroductal 纳米微粒注射液对小鼠颌下腺的治疗

DOI:
10.3791/57521-v

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07:45 min

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May 03, 2018

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, , , , , ,
1Department of Biomedical Engineering,University of Rochester, 2Department of Otolaryngology Head and Neck Surgery,University of Rochester Medical Center, 3Center for Oral Biology,University of Rochester Medical Center

Chapters

  • 00:05Title
  • 00:44Experimental Preparation
  • 01:40Accessing and Visualizing Ductal Entry Point
  • 02:39Ductal Cannulation and Line Placement
  • 05:04Injection
  • 05:52Results: Confirmation of Retroductal Nanoparticle Persistence 24 Hours Post Injection
  • 06:50Conclusion

Summary

Automatic Translation

Automatic Translation

局部药物向颌下腺的传递对了解涎腺生物学和新疗法的发展有很浓厚的兴趣。我们提出了一个更新和详细的 retroductal 注射协议, 旨在提高交付准确性和实验再现性。本文提出的应用是高分子纳米粒子的传递。

Tags

Nanoparticle InjectionSubmandibular GlandRetroductal AdministrationMurine ModelSalivary Gland DysfunctionRadiation TherapyHamilton SyringeCannulationAtropineDissecting MicroscopeTongue ManipulationDuctal Access

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