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在在线 MRI 图像的指导下,对流增强将视遗传阿德诺相关病毒载体输送到 Rhesus Macaque 的皮质
JoVE Journal
Neuroscience
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JoVE Journal
Neuroscience
Convection Enhanced Delivery of Optogenetic Adeno-associated Viral Vector to the Cortex of Rhesus Macaque Under Guidance of Online MRI Images
Please note that all translations are automatically generated.
Click here for the English version.
在在线 MRI 图像的指导下,对流增强将视遗传阿德诺相关病毒载体输送到 Rhesus Macaque 的皮质
DOI:
10.3791/59232-v
•
08:52 min
•
May 23, 2019
•
Karam Khateeb
2
,
Devon J. Griggs
3
,
Philip N. Sabes
,
Azadeh Yazdan-Shahmorad
2,3,4
1
Departments of Bioengineering
,
University of Washington
,
2
Washington National Primate Research Center
,
3
Department of Electrical and Computer Engineering
,
University of Washington
,
4
Department of Physiology and Center for Integrative Neuroscience
,
University of California, San Francisco
Chapters
00:04
Title
00:39
MR-compatible Chamber Implantation
02:05
Viral Vector Delivery
06:18
Results: Validation of Viral Expression
07:47
Conclusion
Summary
Automatic Translation
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Automatic Translation
在这里,我们演示了磁共振 (MR) 引导的对流增强病毒载体到皮层 (CED) 到皮层作为一种有效和简化的方法,以实现光遗传学表达在大型皮质区域在猴脑。
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Convection Enhanced Delivery
Optogenetic
Adeno-associated Viral Vector
Cortex
Rhesus Macaque
MRI
Craniotomy
Dura
MR Compatible Chamber
Injection Grid
Saline
Sterile Absorbable Gel Foam
Vitamin E Capsule
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